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Biotechnology benefits and costs
Modern biotechnology is still a relatively young field, but research results have outpaced the ability of social scientists to adequately evaluate and explain benefits and costs to an understandably wary public. Without informed public debate, potentially useful technologies are lumped together with potentially harmful ones. Informing that debate requires identification of stakeholder concerns, careful socio-political and economic analysis of the level and distribution of benefits and costs, and a concerted effort to educate the public. Aspects of the agricultural biotechnology revolution requiring particular attention are the agricultural-pharmaceutical interactions and the benefits to low-income consumers and producers. Most productivity-enhancing technologies place some group at a disadvantage, so it is important to identify who might gain and who might lose, and by how much. It is also critical to identify the counterfactual of what would happen without further development of these technologies. Another important issue is how to value outcomes that on the benefit side may be high in the aggregate, but on the cost side may have negative effects concentrated on particular groups.

Past studies on benefits and costs of agricultural technologies
There have been many previous analyses of the benefits and costs of agricultural technologies (See Alston, et al, 2000, and Evenson, 2000 for recent reviews) and a few economic assessments of modern agricultural biotechnologies (e.g., Falk-Zepeda, Traxler, and Nelson, 2000; Qaim, 1999, 2000)). Most studies have focused on the benefits of technologies generated through public sector research and extension. The results have generally suggested significant positive benefits to agricultural R&D in the aggregate, with producers who adopt early and low-income consumers benefiting the most. However, biotech, with its significant private sector participation in research, can generate its own distinct benefit patterns, especially if imperfectly competitive firms can retain profits from innovations (Moschini and Lapan, 1997; Alston, Sexton, and Zhang, 1997). Furthermore, growing consumer concern is causing government regulators to move cautiously - perhaps justifiably - affecting the speed with which technologies become available and are adopted. Therefore, it is essential to evaluate public opinion with respect to agricultural biotechnologies and to incorporate those opinions into analylses of the benefits and costs of technological use.

Tobacco biopharmaceuticals
Biotechnologies in tobacco and rice are chosen as the subject for intense scrutiny in this project for several reasons. Tobacco is a crop with major potential for producing pharmaceutical products to replace currently expensive drugs for multiple devastating diseases. Drugs for Gauchers disease, for example, cost about $160,000 per patient per year. It appears that through biotechnology, tobacco may be able to produce the same drug at a fraction of the cost (Cramer, 2001). Tobacco produces biomass very quickly, is a prolific seed producer, and yet can process complex proteins. It is the easiest crop to genetically engineer and is not regulated as a food. Tobacco is a high-value crop of importance in Virginia, North Carolina, Tennessee, and elsewhere in the Southeast, but producers have gradually lost their market due to export competition, health concerns, and other reasons. Pharmaceutical products produced through biotechnology may provide an alternative use for an economically important crop in the South.

Rice biotechnologies
Because rice is a major staple for a large segment of the world population, there are more biotechnologies being researched for rice than for any other crop (Hossain et al, 2000). Technologies for insect resistance, abiotic stress resistance, herbicide resistance, and nutritional enhancement are under development. The research is underway in the United States, Europe, and especially in Asia; the United States is a participant in the international project to sequence the genome of rice. Genetic information on rice is becoming freely and readily available to scientists, and the International Rice Research Institute (IRRI) in particular is heavily invested in rice biotechnology research (IRRI, 1997; Hossain, et al, 2000). For many years, the Rockefeller Foundation also invested in biotechnology research and training in rice in Asia, with the result that several developing country research systems have a small cadre of scientists trained to interact with and build on the research at IRRI. It is critical that public understanding of the benefits and costs of rice biotech keep up with the science at home and abroad.

References
Alston, J.M., G. W. Norton, and PG. Pardey, Science Under Scarcity: Principles and Practice for Agricultural Research Evaluation and Priority Setting, (Ithaca, NY: Cornell University Press, 1995).

Alston, J.M., R.J. Sexton, and M. Zhang, "The Effects of Imperfect Competition on the Size and Distribution of Research Benefits", American Journal of Agricultural Economics, 79(November 1997): 1252-1265.

Alston, J.M., C. Kang, M. Marra, P. Pardey, and J. Wyatt, "Meta-analysis of rates of Return to Agricultural R&D: Ex Pede Herculum", IFPRI Research Report 113, Washington, DC, June 2000.

Cramer, C., personal Communication, Blacksburg, VA, March 28, 2001.

Cuyno, L.C.M., G.W. Norton, and A. Rola, "Economic Analysis of Environmental Benefits of Integrated Pest Management: A Philippines Case Study", Agricultural Economics, (In Press).

Evenson, R.E., "Private and Public Research and Extension", in B.L Gardner and G.C. Rausser, (eds.) Handbook of Agricultural Economics, Volume 1, part 1 (New York: North Holland, forthcoming).

Falk-Zepeda, J.B., G. Traxler, and R.G. Nelson, "Surplus Distribution from the Introduction of Biotechnology Innovation", American Journal of Agricultural Economics, 82 (May 2000): 360-369.

Hossain, M., J. Bennett, S. Datta, H. Leung, and G.Khush, "Biotechnology Research in Rice for Asia: Priorities, Focus, and Directions", Chapter 7 in M. Qaim, F. Krattiger, and J. von Braun (eds.) Agricultural Biotechnologies for Developing Countries: Towards Optimizing the Benefits for the Poor (Dordtrecht, the Netherlands: Kluwer, 2000).

International Rice Research Institute, "Bt Rice: Research and Policy Issues", IRRI information series No 5, Los Baños, Laguna, Philippines, June 1997.

Moschini, G., and H. Lapan, "Intellectual Property Rights and the Welfare Effects of Agricultural R&D" American Journal of Agricultural Economics, 79 (Novenber 1997): 1229-1242.

Mullen, J.D. G.W. Norton, and D.W. Reaves, "Economic Analysis of Environmental Benefits of Integrated Pest Management," Journal of Agricultural and Applied Economics, 29 (December 1997):243-253.

Pearce, D.W., and R.K. Turner, Economics of Natural Resources and the Environment, (Baltimore: Johns Hopkins University Press, 1990).

Pray, C.E., J.Huang, D. Ma, and F. Qiao, "Impact of Bt Cotton in China", Dept of Agr. Food, and Resource Econ., Rutgers University, February, 2000 (mimeo).

Qaim, M., "Potential Benefits of Agricultural Biotechnology: an Example from the Mexican Potato Sector", Review of Agricultural Economics", 21 (1999): 390-408.

Qaim, M., "Welfare Prospects of Transgenic Crops in Developing Countries", Chapter 9 in M. Qaim, F. Krattiger, and J. von Braun (eds.) Agricultural Biotechnologies for Developing Countries: Towards Optimizing the Benefits for the Poor (Dordtrecht, the Netherlands: Kluwer, 2000).

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This project was supported by Initiative for Future Agriculture and Food Systems
Grant no. 2001-52100-11250 from the USDA Cooperative State Research, Education, and Extension Service

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