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Tobacco: Bio-pharming

Bio-Pharming

Some of the newest and most effective drugs that combat illnesses like cancer and heart disease are made from proteins -- picture of a fermentation unitcomplex compounds that can only be synthesized by the cells of living organisms. These proteins, called “biologics”, are currently manufactured in expensive, sterile fermentation facilities where cultures of mammalian cells or micro-organisms are brewed in stainless steel tanks. Now, by applying the tools of biotechnology to commercial crops such as tobacco or corn, plants are being developed that could produce these medicinal compounds.

Producing pharmaceutical products using plants has been a target of scientific research for about 20 years, bridging the fields of molecular biology, medicine, and agriculture. Engineering such specialized “pharm” crops represents the newest wave of agricultural biotechnology, and growing these crops is being called “bio-pharming”. (The first wave of biotechnology applied to modern agriculture gave plants new traits that allow farming to be more efficient. These genetically engineered crops -- mostly corn, cotton, and soybeans -- have been modified to picture of a combine harvesting cropscontain built-in resistance to insects or herbicides, and have been adopted widely by farmers in the U.S.)

Bio-pharming has the potential to change the drug producing industry by enabling new, and larger quantities of medicines to be manufactured more cheaply. While no plant-made pharmaceuticals are currently on the market, the sentiment among the research community is that this barrier will be broken within the next five to ten years.

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Last updated: June 2006


This project was supported by Initiative for Future Agriculture and Food Systems
Grant no. 2001-52100-11250 from the USDA Cooperative State Research, Education, and Extension Service

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